Monthly Archives: April 2016

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Burton’s team tested the ability of two antibodies from b12, called KA and LALA using the prevent infection using the SHIV / macaque model, to be challenged in the macaque with a hybrid human – simian virus that infects the model but is recognized human antibodies. KA antibodies contain a mutation which is, by the interaction with the complement In contrast, the the immune system responsible for preventing the destruction of invading pathogens. The LALA antibodies contain a mutation that renders it not interact with either the complement pathway or the Fc receptor.

In addition to Burton, Hessell and Hangartner, authors of the study, ‘Fc receptor but not complement binding is important antibodies for protection against HIV, ‘are Meredith Hunter and Preston A. Marx of Tulane University; Carin EG Havenith, Frank J. Beurskens, Joost M. Bakker and Paul WHI Parren of Genmab , Gary Landucci and Donald N. Forthal the University of California, School of Medicine, and Caroline Lanigan of The Scripps Research Institute. Continue reading

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