In the 26th November issue / iu003e Cell, Spector and a team led by student Jeremy Wilusz report their discovery of a previously unknown mechanism in the cell nucleus that processes non-coding RNA molecules.. And what about the other 98 percent of the genome? It was thought by many that genetic junk, a massive accumulation of code that evolution is superfluous. But now scientists are discovering that the majority the DNA in our genomes, while it is not code for the specific RNA molecules that serve as templates for protein synthesis, but not perform different types of work. But what kind of work, what kinds of cellular mechanisms? Because of their relative abundance needing non-coding DNA and RNA targets for inviting experiments.

For coding RNAs In this way sequence has been read off a DNA template, which protects the new molecule from degradation a molecular complex snips from the tail end of the new block and pens on a signal at its end, and mark them for export out of the nucleus. In non-coding MALAT1 but the CSHL team found the protective signal was already embedded within the molecule, just before the part that later superseded, to constitute mascRNA. The molecular complex responsible for cleaving MALAT1 therefore knew precisely where to make its cut – right after the embedded signal – rather than at MALAT1 end the tail.Funding: Prostate Cancer Specialized Program Research Excellence, the National Cancer Institute, ORDER Cancer Center in.

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