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‘The association remained significant when just patients with serious IVH were analyzed and in addition when sufferers with early – and late-onset sepsis were excluded from the evaluation,’ write the experts. Their findings ‘indicate that a reduced platelet count potentiates the chance for bleeding in the presence of COX inhibitors,’ conclude Kiechl-Kohlendorfer and colleagues. They add that having less association between COX inhibitor treatment and IVH in the absence of moderate thrombocytopenia ought to be interpreted cautiously, as the scholarly study had not been powered to identify associations of moderate power.

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